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INR Patient Self-Testing: Yesterday, Today and Beyond
David Phillips
Independent ConsultantIn the 1920’s … cattle were dying due to unknown
hemorrhagic disease.
• Traced to improperly cured sweet clover.
• Active agent is dicumarol, which is derived from coumarin, a sweet-smelling but coagulation-inactive
chemical found in clover.
• A Vitamin K antagonist or VKA.
• Therapeutic agent – Named for discovery by the
Wisconsin Alumni Research Foundation and the
ending -arin, indicating its link with coumarin.
• Initially and today marketed as a pesticide against rats and mice.
• Approved for use as a medication in 1954.
• Warfarin or trade name Coumadin marketed by DuPont until sold to BMS in 2001. • Barr was first generic to enter the market in 1997. Crystalline Warfarin SodiumIn the 1920’s … cattle were dying due to unknown
hemorrhagic disease.
• Traced to improperly cured sweet clover.
• Active agent is dicumarol, which is derived from coumarin, a sweet-smelling but coagulation-inactive
chemical found in clover.
• A Vitamin K antagonist or VKA.
• Therapeutic agent – Named for discovery by the
Wisconsin Alumni Research Foundation and the
ending -arin, indicating its link with coumarin.
• Initially and today marketed as a pesticide against rats and mice.
• Approved for use as a medication in 1954.
• Warfarin or trade name Coumadin marketed by DuPont until sold to BMS in 2001. • Barr was first generic to enter the market in 1997. Crystalline Warfarin Sodium
(Coumadin®)In the 1920’s … cattle were dying due to unknown
hemorrhagic disease.
• Traced to improperly cured sweet clover.
• Active agent is dicumarol, which is derived from coumarin, a sweet-smelling but coagulation-inactive
chemical found in clover.
• A Vitamin K antagonist or VKA.
• Therapeutic agent – Named for discovery by the
Wisconsin Alumni Research Foundation and the
ending -arin, indicating its link with coumarin.
• Initially and today marketed as a pesticide against rats and mice.
• Approved for use as a medication in 1954.
• Warfarin or trade name Coumadin marketed by DuPont until sold to BMS in 2001. • Barr was first generic to enter the market in 1997. Crystalline
...